First-Generation Antihistamines: Relief Today, Problems Tomorrow
First-generation antihistamines, like diphenhydramine, are widely used for allergies but may contribute to cognitive decline due to their anticholinergic properties.
Recent studies found that continued use is associated with an increased risk of dementia.
For long-term allergy treatment, safer alternatives such as cetirizine are preferable. Always consult your doctor before using these drugs for extended periods.
Tricyclic Antidepressants and Memory Loss
Tricyclic antidepressants, such as amitriptyline, increase the availability of certain neurotransmitters but also have anticholinergic effects. This combination raises the risk of dementia and cognitive decline, particularly in older adults.
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